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I spy breast cancer trial

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Spy 1 in patients with triple negative breast cancer receiving dose dense AC x 4 followed by dose dense taxol x 4 given every 2 weeks in combination with carboplatin at 6 AUC every 4 weeks. Patients with triple negative breast cancer will be treated with a novel chemotherapy regimen in the adjuvant setting which adds carboplatin to a standard anthracycline and taxol based regimen. Patient's tumor will be tested for a novel protein expression regulator, Spy Levels of Spy-1 and Spymediated genes will be tested for correlation with poor response to therapy, even in the presence of wild-type p This may determine the efficacy of targeting this pathway for novel therapeutic design as well as utilizing this pathways as a prognostic marker for this population of patients. This patient population is defined as those that were negative for estrogen, progesterone and HER2neu.
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Foundation for the NIH Announces First Results of I-SPY 2 Breast Cancer Clinical Trial

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I-SPY 2, a Clinical Trial Model that is Revolutionizing Treatment

Please complete this secure form. The information you provide will help us assist you as efficiently as possible. A representative will contact you within one to two business days to help you schedule an appointment. To request an appointment, please use our secure online form. In the I-SPY 2 clinical trial, adding the checkpoint blocker pembrolizumab KeytrudaTM to standard therapy dramatically improved response rates for patients with invasive triple-negative breast cancer TNBC , tumors that lack estrogen and progesterone receptors as well as HER2. Sixty percent of the women with TNBC who received pembrolizumab in addition to standard therapy had a pathological complete response no evidence of cancer in the breast or lymph nodes compared to 20 percent of the women who received standard chemotherapy alone. For women with hormone-receptor positive, HER2 negative disease, the complete response rate for patients who received associate standard therapy plus pembrolizumab nearly tripled, from 13 percent to 34 percent.
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I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

Metrics details. Neoadjuvant chemotherapy is increasingly given preoperatively to shrink breast tumours prior to surgery. This approach also provides the opportunity to study the molecular changes associated with treatment and evaluate whether on-treatment sequential samples can improve response and outcome predictions over diagnostic or excision samples alone.
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The I-SPY 2 trial uses a unique adaptive design to match experimental therapies with patients. Genetic or biological markers "biomarkers" from individual patients' tumors are used to screen promising new treatments, identifying which treatments are most effective in specific types of patients. The adaptive trial design enables researchers to use early data from one set of patients to guide decisions about which treatments might be more useful for patients later in the trial, while minimizing the exposure of patients to treatments that do not benefit them. Eligible patients enrolled in the trial are randomly assigned to standard neoadjuvant chemotherapy, including paclitaxel, followed by anthracycline-based chemotherapy, or they receive paclitaxel in combination with a novel agent followed by anthracycline-based chemotherapy before surgery. Each woman has a four-to-one chance of being randomized to receive an experimental agent.
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Video сomments(7)
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